十大正规博彩网站评级正规博彩平台卫生 researchers studying hand screening technique for early diagnosis of life-threatening multi-system disorder

Cardiologists, orthopaedic surgeons, and pathologists at 十大正规博彩网站评级正规博彩平台卫生’s Dartmouth Hitchcock Medical Center (DHMC) are collaborating on groundbreaking research aimed at identifying early signs of amyloidosis, 一种进行性多系统疾病. This condition occurs when amyloid protein accumulates in various organs, including the heart, internal organs, nervous system, musculoskeletal system, and digestive tract. 我们的目标 of this research is to diagnose amyloidosis years before it leads to life-threatening organ failure and other complications.

淀粉样变性常被误诊, and by the time a patient presents with cardiac symptoms, 预后很差, 平均存活时间为3-4年,萨拉说. 阿里博士, cardiovascular fellow at DHMC’s 心脏和血管 Center and study co-investigator. "While there is now an effective treatment available to slow down the progression of the disease, it cannot reverse the damage that has already occurred."

The research team is focusing their research on an often-overlooked location—the hand—in order to detect early evidence of amyloidosis and develop screening guidelines for the condition.

“在更大的空间，比如心脏, it takes years for amyloid deposits to become significant enough to cause symptoms,文森特·D说。. 本赛季,小., MD, orthopaedic hand surgeon and study co-investigator. “然而, 在手和手腕的小空间, amyloid deposits within the lining of the tendons and nerves may cause symptoms such as trigger finger or carpal tunnel years before cardiac symptoms manifest."

在一起, the orthopaedic surgery and cardiology teams have pioneered a protocol to screen all men over the age of 50 and women over the age of 60 who present with symptoms of bilateral carpal tunnel for amyloidosis. This is achieved by performing routine flexor tenosynovial biopsies during carpal tunnel release procedures.

"We believe that the bilaterality of the carpal tunnel presentation indicates a systemic problem, and we know that men tend to develop amyloidosis earlier than women,兰斯·G说。. Warhold, MD, orthopaedic hand surgeon and study co-investigator. “通过我们的研究, we aim to determine who is at the highest risk for amyloidosis and how we can most effectively screen for the condition."

While synovial tissue biopsies for amyloidosis used to be a standard practice during carpal tunnel release procedures performed four decades ago, it fell out of favor due to the lack of effective treatment options and limited patient benefit resulting from early diagnosis.

"If a patient has a positive biopsy for amyloid deposits in the wrist, 它们也可能在心脏中有可检测到的沉积物,Max J解释道。. Biondi, MD, cardiovascular fellow at DHMC’s 心脏和血管 Center and study co-investigator. "When orthopaedic surgeons identify the condition through biopsy, 他们会把病人转到心脏病科, enabling our team to conduct a comprehensive evaluation, 进行诊断, and initiate treatment before cardiac symptoms develop. If there is no evidence of amyloid deposits during our evaluation, we can start surveillance imaging."

阿里强调了早期诊断的重要性, 分享, "With effective treatment for amyloidosis now available, 早期诊断可以挽救生命. 这就是为什么这项研究如此重要."